The adverse events rate is low when Propofol is administered by a trained professional such as a CRNA.
In a recent article published in Clinical Gastroenterology and Hepatology, a study was performed with patients undergoing a variety of endoscopic procedures with sedative dosing administered by a CRNA. This article stated, “… this is the first paper to report the frequency of airway modification associated with the use of propofol in endoscopy.” The article continued to highlight the importance and need for trained personnel, such as CRNA’s, to monitor patients during sedation with propofol. The conclusion by Sreenivasa Jonnalagadda M.D., the lead author of the article, confirmed ” … Highest-risk patients should be managed by nurse anesthetists trained in advanced airway interventions…” .
For further reference and information please see the April 2010 Clinical Gastroenterology and Hepatology Journal.